![]() ![]() There are a number of different pill styles and effects. These go into your Q slot and are one-time-use items. Collectible items can be obtained in a variety of ways and most are unique in that, once appearing in game, they will never appear again during that session. These cannot be removed and are individually counted on the collection screen. ![]() These Items, when picked up, add a permanent effect to Isaac. ![]() Most activated items can only appear once per game with few exceptions, so leaving behind an activated item is typically a permanent choice. An activated item can be used by pressing space, and unlike a pill or card, activated items recharge over time and can be reused when ready.
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